Increased microerythrocyte count in homozygous alpha(+)-thalassaemia contributes to protection against severe malarial anaemia.
The heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis Midi Interface of alpha-globin chains that form part of normal adult haemoglobin (Hb).Individuals homozygous for alpha(+)-thalassaemia have microcytosis and an increased erythrocyte count.Alpha(+)-thalassaemia homozygosity confers considerable protection agains